Photo-Fenton-Like (Trideutero)methylsulfonylation/Remote (Benzo)thiazolyl Migration Cascade of Unactivated Alkenes with DMSO(- <i>d</i> <sub>6</sub> )
We report a visible-light photocatalytic, transition-metal-free methylsulfonylation/distal (benzo)thiazolyl migration cascade of unactivated alkenes using DMSO or DMSO- d 6 as methylsulfonyl or trideuteromethylsulfonyl sources. The corresponding sulfonyl radicals add selectively to the terminal alkene carbon and trigger distal migration. Mechanistic studies support hydroxyl-radical generation through a photo-Fenton-like process involving water and oxygen, without externally added hydrogen peroxide, thereby avoiding metal leaching and catalyst deactivation.
Authors
- Q F Liu
- Yang Zm
- H L Liu
- Guanghui Lv (ORCID: https://orcid.org/0000-0003-4846-9564)
- Tianle Huang (ORCID: https://orcid.org/0009-0009-0184-7899)
- Hui Li (ORCID: https://orcid.org/0000-0001-9198-3951)
- Zhihang Tang (ORCID: https://orcid.org/0000-0003-4643-5483)
- Yan Wu (ORCID: https://orcid.org/0000-0002-0116-2883)
- R Wang
- Shengqing Yu
- Hui Song
Institutions
- Hubei University of Medicine (CN)
- US Forest Service (US)
- Ministry of Education of the People's Republic of China (CN)
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Taihe Hospital (CN)
- The Medical Device (United Kingdom) (GB)
- Pharmaceuticals and Medical Devices Agency (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-22
- DOI
- https://doi.org/10.1021/acs.orglett.6c02449
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00