Peptidomimetic Pillar[5]arene Derivatives Bearing Aromatic α-Amino Acid Fragments as Supramolecular Shields: Preventing Adverse Cyclosporine A–Calcium Ion Interactions
system demonstrated a protective function, suppressing the undesirable interaction of the immunosuppressant with calcium ions, despite the drug's high intrinsic affinity for this macroelement. The results highlight the promise of these peptidomimetic macrocycles as supramolecular shields for mitigating uncontrolled drug-ion interactions in disrupted homeostasis.
Authors
- Luidmila S. Yakimova (ORCID: https://orcid.org/0000-0003-3956-6637)
- Igor A. Sedov (ORCID: https://orcid.org/0000-0003-0438-5991)
- Timur A. Mukhametzyanov (ORCID: https://orcid.org/0000-0003-2645-5110)
- Anastasia Nazarova (ORCID: https://orcid.org/0000-0003-4540-2364)
- Davletshin Dm
- Vildan Sultanaev (ORCID: https://orcid.org/0000-0002-3940-5158)
- Ivan I. Stoikov (ORCID: https://orcid.org/0000-0002-3019-7866)
- Elvina M. Gilyazova
- Emil R. Bulatov
- Olga A. Mostovaya
Institutions
- Kazan Federal University (RU)
Publication Details
- Journal
- Langmuir
- Published
- 2026-07-22
- DOI
- https://doi.org/10.1021/acs.langmuir.6c02094
- Primary Topic
- Supramolecular Chemistry and Complexes
- Type
- article
- Field-Weighted Citation Impact
- 0.00