Interpretable deep learning framework for secure clinical data analytics

Abstract The growing use of artificial intelligence in the healthcare sector has facilitated the emergence of sophisticated clinical data analytics, but the most critical issues pertain to data privacy, model interpretability, and model trustworthiness. These problems still pose a challenge to its real-world application. This study proposes an interpretation of a deep learning framework for secure clinical data analytics. This proposes a privacy-preserving distributed learning framework in combination with a naturally interpretable model structure. The suggested framework enables parallel training across several healthcare facilities without compromising raw patient information, thereby keeping the data confidential without adversely affecting the analysis. An idea-driven deep learning framework is also presented to produce clinically significant intermediate representations that enable clear, interpretable predictions. Moreover, a new explanation stability mechanism is established to maintain the consistency and reliability of model explanations in distributed environments. To promote clinical safety, the decision module includes uncertainty to enable the system to detect predictions with low confidence and defer them to experts. Massive tests using actual clinical data on patient conditions can be conducted to demonstrate that the framework presented is much more successful than other methods with respect to predictiveness, interpretability, explanation stability, fairness, and calibration. Furthermore, the framework demonstrates that privacy preservation, interpretability, explanation reliability, and clinical usability can be jointly optimized within a unified learning architecture. The findings indicate the effectiveness of the suggested strategy in providing secure, transparent, and reliable clinical decision support, rendering it an appropriate strategy to implement in contemporary healthcare systems.

Authors

Publication Details

Journal
Scientific Reports
Published
2026-07-22
DOI
https://doi.org/10.1038/s41598-026-62055-8
Primary Topic
Privacy-Preserving Technologies in Data
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Interpretable deep learning framework for secure clinical data analytics

Deema Mohammed Alsekait, Omar Kassem Khalil, Kholoud Alkayid, Abdulghani Bakur Alsayegh et al.
Scientific Reports
Privacy-Preserving Technologies in Data
article

Interpretable deep learning framework for secure clinical data analytics

Deema Mohammed Alsekait, Omar Kassem Khalil, Kholoud Alkayid, Abdulghani Bakur Alsayegh, Amar Y. Jaffar, K. M. Baalamurugan, Mahmoud Ahmad Al-Khasawneh, P. Karthik
article en

Abstract

Abstract The growing use of artificial intelligence in the healthcare sector has facilitated the emergence of sophisticated clinical data analytics, but the most critical issues pertain to data privacy, model interpretability, and model trustworthiness. These problems still pose a challenge to its real-world application. This study proposes an interpretation of a deep learning framework for secure clinical data analytics. This proposes a privacy-preserving distributed learning framework in combination with a naturally interpretable model structure. The suggested framework enables parallel training across several healthcare facilities without compromising raw patient information, thereby keeping the data confidential without adversely affecting the analysis. An idea-driven deep learning framework is also presented to produce clinically significant intermediate representations that enable clear, interpretable predictions. Moreover, a new explanation stability mechanism is established to maintain the consistency and reliability of model explanations in distributed environments. To promote clinical safety, the decision module includes uncertainty to enable the system to detect predictions with low confidence and defer them to experts. Massive tests using actual clinical data on patient conditions can be conducted to demonstrate that the framework presented is much more successful than other methods with respect to predictiveness, interpretability, explanation stability, fairness, and calibration. Furthermore, the framework demonstrates that privacy preservation, interpretability, explanation reliability, and clinical usability can be jointly optimized within a unified learning architecture. The findings indicate the effectiveness of the suggested strategy in providing secure, transparent, and reliable clinical decision support, rendering it an appropriate strategy to implement in contemporary healthcare systems.

Scientific Reports
Peace, Justice and strong institutions
Openalex Percentile: Top 6%
Privacy-Preserving Technologies in Data
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.