Fly neurons carry a molecular ‘timestamp’ that encodes their birth order

A single-cell gene-expression atlas of the fly nerve cord mapped onto its wiring diagram has uncovered a simple shared gene-expression code. The code enables neurons to carry a molecular memory of the order of their birth from a parent cell, and shapes their diversity. The gene-expression code is shared across neurons born from all the stem cells that produce the fly central brain and nerve cord.

Publication Details

Journal
Nature
Published
2026-07-22
DOI
https://doi.org/10.1038/d41586-026-02240-x
Primary Topic
Developmental Biology and Gene Regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Fly neurons carry a molecular ‘timestamp’ that encodes their birth order

Nature
Developmental Biology and Gene Regulation
article

Fly neurons carry a molecular ‘timestamp’ that encodes their birth order

article en

Abstract

A single-cell gene-expression atlas of the fly nerve cord mapped onto its wiring diagram has uncovered a simple shared gene-expression code. The code enables neurons to carry a molecular memory of the order of their birth from a parent cell, and shapes their diversity. The gene-expression code is shared across neurons born from all the stem cells that produce the fly central brain and nerve cord.

Nature
Openalex Percentile: Top 14%
Developmental Biology and Gene Regulation
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Fly neurons carry a molecular ‘timestamp’ that encodes their birth order · Nature (2026) | TGRS Research Map | TGRS