Case Report: Rapid improvement of chronic lymphocytic leukemia infiltration of the scalp by BCL2-inhibitor

Introduction Chronic lymphocytic leukemia (CLL) is a malignancy of mature CD5+ B-lymphocytes. While it typically involves the peripheral blood, the bone marrow, the lymph nodes, and the spleen, cutaneous infiltration—leukemia cutis—is a rare manifestation of the disease, causing aesthetic problem to the patients. Case Presentation A 60-year-old man with a two-year history of CLL presented with a scalp plaque. Biopsy confirmed leukemic skin infiltration. The patient was started on Obinutuzumab and Venetoclax. Following an infusion reaction, Venetoclax monotherapy continued, leading to rapid improvement. Conclusion Cutaneous infiltrates in CLL patients are a rare manifestation with unclear prognostic significance, typically occurring after diagnosis, as in our case. New therapies for CLL, such as BCL2 inhibitors, not only offer more effective disease control but also appear to help manage associated cutaneous infiltrates, as in our patient.