A confirmatory trial of hysterectomy with minimal parametrectomy for stage IB1 cervical cancer involving a tumor diameter of 2 cm or less: a Japan Clinical Oncology Group study (JCOG1101)
Objective:The standard surgery for stage IB uterine cervical cancer is radical hysterectomy (RH).However, RH is highly invasive, and there is a need to establish less invasive techniques.Methods: We conducted a prospective, single-arm trial to evaluate the efficacy and safety of modified radical hysterectomy (MRH)in patients with International Federation of Gynecology and Obstetrics 2008 stage IB1 cervical cancer involving a tumor diameter of ≤2 cm measured on magnetic resonance imaging.The protocol treatment consisted of MRH and adjuvant (chemo)radiotherapy if indicated.The primary endpoint was 5-year
Authors
- Nobuo Yaegashi (ORCID: https://orcid.org/0000-0003-2521-039X)
- Toshiaki Saito (ORCID: https://orcid.org/0000-0003-4068-5676)
- Takahiro Kasamatsu (ORCID: https://orcid.org/0000-0003-0693-3250)
- Takafumi Toita (ORCID: https://orcid.org/0000-0003-3907-0228)
- Daisuke Aoki (ORCID: https://orcid.org/0000-0002-9596-8326)
- Haruhiko Fukuda (ORCID: https://orcid.org/0000-0002-6332-4745)
- Ikuo Konishi (ORCID: https://orcid.org/0000-0002-4284-9569)
- Kimio Ushijima (ORCID: https://orcid.org/0000-0002-6087-8873)
- Kazuhiro Takehara (ORCID: https://orcid.org/0000-0001-8808-3338)
- Takahide Arimoto
- Hiroaki Kobayashi (ORCID: https://orcid.org/0000-0003-2491-2189)
- Takashi Onda (ORCID: https://orcid.org/0000-0002-9935-3783)
- Harushige Yokota
- Shoji Kamiura (ORCID: https://orcid.org/0000-0002-5723-8891)
- Toru Nakanishi (ORCID: https://orcid.org/0000-0002-6891-3506)
- Ryunosuke Machida (ORCID: https://orcid.org/0000-0002-3734-6203)
- Hirokuni Takano (ORCID: https://orcid.org/0000-0002-6465-7883)
- Toyomi Satoh (ORCID: https://orcid.org/0000-0002-6929-5463)
- Satoshi Yamaguchi (ORCID: https://orcid.org/0000-0002-8260-6174)
- Toshiaki Nakamura (ORCID: https://orcid.org/0000-0001-9157-2431)
Institutions
- University of Tsukuba (JP)
- Kyoto University (JP)
- St. Luke's International Hospital (JP)
- National Hospital Organization Kyushu Cancer Center (JP)
- Tohoku University Hospital (JP)
- Kurume University Medical Center (JP)
- Tokyo Metropolitan Bokutoh Hospital (JP)
- Keio University Hospital (JP)
- Kagoshima University Hospital (JP)
- Okinawa Prefectural Chubu Hospital (JP)
- Kagoshima City Hospital (JP)
- Saitama Cancer Center (JP)
- Aichi Cancer Center (JP)
- Jikei University Kashiwa hospital (JP)
- Shikoku Cancer Center (JP)
- Japan Clinical Cancer Research Organization (JP)
- Osaka International Cancer Institute (JP)
- Hyogo Prefectural Cancer Center (JP)
- Toranomon Hospital (JP)
Publication Details
- Journal
- Journal of Gynecologic Oncology
- Published
- 2026-07-22
- DOI
- https://doi.org/10.3802/jgo.2027.38.e8
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development