Local prevalence of ceftriaxone resistance informs optimal deployment of new gonorrhea treatments
Abstract Numerous factors may influence the optimal rollout of new gonococcal antibiotics. We compared eight rollout strategies using a gonorrhea transmission model and ranked strategies by the number of gonococcal infections and clinically useful antibiotic lifespan. Rankings were most sensitive to the starting ceftriaxone resistance prevalence and screening frequency.
Authors
- Yonatan H. Grad (ORCID: https://orcid.org/0000-0001-5646-1314)
- Minttu M. Rönn (ORCID: https://orcid.org/0000-0002-9292-5670)
- Roger D. Kouyos (ORCID: https://orcid.org/0000-0002-9220-8348)
- Nicola Low (ORCID: https://orcid.org/0000-0003-4817-8986)
- Kirstin Roster (ORCID: https://orcid.org/0000-0003-3468-2014)
- C C Au
- Eva R Gorenburg
- Dennis K Partl
- Nanina Anderegg
- Pia Abel zur Wiesch
- Fernando P Martinez
Institutions
- University of Bern (CH)
- Harvard University (US)
- University of Washington (US)
- University of Zurich (CH)
- University Hospital of Zurich (CH)
- Global Antibiotic Research & Development Partnership (CH)
- Institute of Social and Preventive Medicine (CH)
- Harvard Global Health Institute (US)
- Stanford University (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-07-17
- DOI
- https://doi.org/10.1093/ofid/ofag447
- Primary Topic
- Reproductive tract infections research
- Type
- article
- Field-Weighted Citation Impact
- 0.00