Self-Sustaining Catalytic–Immunological Cycle Powered by a Tumor Microenvironment-Engineered Iridium–MnO <sub>2</sub> Nanozyme for Photodynamic Immunotherapy
, the system relieves hypoxia and reverses immunosuppression. Overall, this work introduces an innovative nanoplatform that establishes a self-reinforcing cycle of hypoxia alleviation and immune activation, offering a potent combinatorial strategy to surmount PDT resistance and amplify antitumor immunity.
Authors
- Cai‐Ping Tan (ORCID: https://orcid.org/0000-0003-3583-8367)
- Qing‐Hua Shen (ORCID: https://orcid.org/0000-0001-8359-9626)
- P P Wang
- Z Y Li (ORCID: https://orcid.org/0009-0005-8068-8574)
- Long‐Bo Yu
- Ying-Ying Han
Institutions
- Sun Yat-sen University (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-07-18
- DOI
- https://doi.org/10.1021/acs.jmedchem.6c01509
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities
- Basic and Applied Basic Research Foundation of Guangdong Province