Iminyl Radical-Mediated Deconstructive Epoxidation of Allylic Peroxides to Epoxynitriles
Herein, we disclose a visible-light-induced, iminyl-radical-triggered deconstructive epoxidation of allylic peroxides that enables facile access to distal cyano-substituted epoxides. The operationally simple and modular strategy allows the transformation of allylic peroxides and cycloketone oxime derivatives into functionalized epoxides with a broad substrate scope and functional-group tolerance.
Authors
- Chao Shu (ORCID: https://orcid.org/0000-0002-4722-2714)
- Siyu Lu (ORCID: https://orcid.org/0000-0003-4538-7846)
- Xiaoyu Liu (ORCID: https://orcid.org/0009-0001-8033-1517)
- Mingqian Zhou
- Yu Jia
- Ziyang Li
Institutions
- Central China Normal University (CN)
- Wuhan Institute of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-18
- DOI
- https://doi.org/10.1021/acs.orglett.6c02164
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Central China Normal University
- Science and Technology Department of Hubei Province