Biofabrication and biomedical manufacturing research frontiers in the United States
Abstract Biofabrication and biomedical manufacturing are inherently multidisciplinary, integrating living systems with advanced manufacturing to create functional products for applications spanning regenerative engineering and medicine, in vitro disease modeling, drug discovery, and medical devices. As these technologies develop, they are emerging as core enablers of next-generation healthcare and life-science innovation. In the United States (U.S.), rapid progress across fabrication processes, material systems, physics-based modeling, and translation-oriented strategies is expanding the achievable design space and accelerating movement from laboratory demonstrations toward clinical and commercial deployment. We introduce major U.S. research frontiers and highlight representative advances in this field that support applications including organoids and other microphysiological systems for in vitro testing, engineered tissue constructs for in vivo use, and medical devices and biohybrid platforms. We further provide an outlook on advancing robust, ethical biofabrication and biomedical manufacturing in the U.S. research ecosystem.
Authors
- Amit Bandyopadhyay (ORCID: https://orcid.org/0000-0003-0992-5387)
- Leon M. Bellan (ORCID: https://orcid.org/0000-0001-7181-2194)
- Marc Ferrer (ORCID: https://orcid.org/0000-0003-4569-9137)
- Scott J. Hollister (ORCID: https://orcid.org/0000-0001-7625-892X)
- 丁爱祥
- Thomas E. Angelini (ORCID: https://orcid.org/0000-0002-0313-4341)
- Rohan A. Shirwaiker (ORCID: https://orcid.org/0000-0002-0215-2847)
- Shaochen Chen (ORCID: https://orcid.org/0000-0001-6876-497X)
- Zhijian Pei (ORCID: https://orcid.org/0000-0003-2280-4694)
- Susmita Bose (ORCID: https://orcid.org/0000-0001-8601-016X)
- Debolina Ghosh (ORCID: https://orcid.org/0000-0002-8681-9812)
- Changxue Xu (ORCID: https://orcid.org/0000-0002-5323-595X)
- Liqun Ning (ORCID: https://orcid.org/0000-0002-3651-7410)
- Nasim Annabi (ORCID: https://orcid.org/0000-0003-1879-1202)
- Yong Hong Huang (ORCID: https://orcid.org/0000-0002-4691-7370)
- Bashir Khoda (ORCID: https://orcid.org/0000-0002-3229-343X)
- Langer Rs
- Bin Duan (ORCID: https://orcid.org/0000-0003-3302-1900)
- Eben Alsberg (ORCID: https://orcid.org/0000-0002-3487-4625)
- Yifei Jin (ORCID: https://orcid.org/0000-0003-4336-1802)
- Gabor Forgács
- R Vignesh Narayan
- Yu Shrike Zhang (ORCID: https://orcid.org/0000-0002-0045-0808)
- Warren L. Grayson (ORCID: https://orcid.org/0000-0001-6099-6469)
- Jayant Saksena
- Ali Tamayol (ORCID: https://orcid.org/0000-0003-1801-2889)
- Brenda M. Ogle (ORCID: https://orcid.org/0000-0001-7613-7490)
- Lijie Grace Zhang (ORCID: https://orcid.org/0000-0003-3009-045X)
- Roland K. Chen (ORCID: https://orcid.org/0000-0002-6765-6667)
- Michael Mak (ORCID: https://orcid.org/0000-0001-6881-8130)
- Krishanu Saha (ORCID: https://orcid.org/0000-0003-2837-0858)
- Adriana Blazeski (ORCID: https://orcid.org/0000-0002-1536-5307)
- Murat Güvendiren (ORCID: https://orcid.org/0000-0002-3475-1051)
- CT Laurencin
- Pranav Soman (ORCID: https://orcid.org/0000-0001-9456-0030)
- Wei Li (ORCID: https://orcid.org/0000-0003-2091-8188)
- Yunxia Chen (ORCID: https://orcid.org/0000-0001-8398-8226)
- Sang Jin Lee (ORCID: https://orcid.org/0000-0002-3899-1909)
- James J. Yoo (ORCID: https://orcid.org/0000-0002-7827-3848)
- Congrui Jin
- Kyle R. Phillips
- David Dean
- Elizabeth Cosgriff-Hernandez
- John P. Fisher
- Ashley Hicks
- L Bertassoni
- Yunzhi Peter Yang
- Ming C. Leu
- Ibrahim T. Ozbolat
- Thomas Boland
- Albert Shih
- Peihua Qiu
- Vahid Serpooshan
- Paul D. Dalton
- Kam W. Leong
- Anthony Atala
- Mark W. Tibitt
- Jason A. Burdick
- Roger D. Kamm
- Douglas B. Chrisey
- Christopher S. Chen
- Robert C. Chang
- Amir K. Miri
- MD Ahasan Habib
- Sarah C. Heilshorn
Institutions
- Forest Institute (US)
- Cleveland State University (US)
- Broad Institute (US)
- Stevens Institute of Technology (US)
- Boston University (US)
- Tulane University (US)
- New Jersey Institute of Technology (US)
- Texas Tech University (US)
- Brigham and Women's Hospital (US)
- University of Minnesota (US)
- Georgia Institute of Technology (US)
- University of Nevada, Reno (US)
- University of Wisconsin–Madison (US)
- Harvard University (US)
- North Carolina State University (US)
- University of Connecticut (US)
- Johns Hopkins University (US)
- Rochester Institute of Technology (US)
- University of California, Los Angeles (US)
- The University of Texas at El Paso (US)
- Oregon Health & Science University (US)
- University of Oregon (US)
- University of Colorado Boulder (US)
- George Washington University (US)
- California Institute for Regenerative Medicine (US)
- Vanderbilt University (US)
- Missouri University of Science and Technology (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Providence Portland Medical Center (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Wisconsin Institutes for Discovery (US)
- University of Florida (US)
- ETH Zurich (CH)
- University of California San Diego (US)
- University of Illinois Chicago (US)
- University of Chicago (US)
- Adult Congenital Heart Association (US)
- La Jolla Bioengineering Institute (US)
- Regenerative Medicine Institute (MX)
- Jesse Brown VA Medical Center (US)
- National Center for Advancing Translational Sciences (US)
- Harvard Stem Cell Institute (US)
- The University of Texas Health Science Center (US)
- Walker (United States) (US)
- Wake Forest University (US)
- University of Nebraska Medical Center (US)
- Stony Brook University (US)
- Massachusetts Institute of Technology (US)
- University of Maryland, College Park (US)
- Syracuse University (US)
- University of Portland (US)
- Washington State University (US)
- UConn Health (US)
- University of Missouri (US)
- Columbia University (US)
- University of Maine (US)
- The University of Texas at Austin (US)
- New Jersey City University (US)
- Texas A&M University (US)
- Stanford University (US)
Publication Details
- Journal
- Bio-Design and Manufacturing
- Published
- 2026-07-17
- DOI
- https://doi.org/10.1631/bdm.2600246
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00