Improved Protein Identification in Native Ambient Mass Spectrometry by the Integration of Proton Transfer Charge Reduction and Higher-Energy Collision Dissociation (PTCR-HCD MS <sup>3</sup> )
also removes interference from overlapping lipid species which can similarly affect confident protein identification. The approach also allows identification of proteins that are masked at the MS1 level but are revealed following PTCR.
Authors
- Sarah Vickers (ORCID: https://orcid.org/0009-0003-0157-9181)
- Helen J. Cooper (ORCID: https://orcid.org/0000-0003-4590-9384)
- Rebecca L. Edwards (ORCID: https://orcid.org/0000-0002-9612-8898)
- Oliver J. Hale (ORCID: https://orcid.org/0000-0002-2286-5780)
Institutions
- University of Birmingham (GB)
Publication Details
- Journal
- Journal of the American Society for Mass Spectrometry
- Published
- 2026-07-17
- DOI
- https://doi.org/10.1021/jasms.6c00165
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- Engineering and Physical Sciences Research Council