Calibration-free GRAPE pTx pulses for homogeneous spatial-selective excitation at 7T

PurposeExtend the Universal Pulse GRAPE formalism to pulses with a defined spectral response, and apply the concept to spatial selection.MethodsWe added Bloch simulations at several frequencies for each voxel to the pulse calculation to create universal spectrally-selective GRAPE pulses. With a superimposed constant gradient field spatial selection was achieved. The method was tested in slice- and slab-selective imaging experiments.ResultsUniversal spatially-selective GRAPE pulses increased FA homogeneity and SNR. In 2D gradient echoes, the SNR could be increased by approximately 6% compared to CP pulses, and in a slabselective TSE sequence, the SNR increased by 29% against kT -spokes pulses. Additionally, the slab-selective GRAPE pulse proved to be more robust against B0 deviations and is significantly shorter in comparison to kT -spokes pulses while maintaining a similar FA homogeneity.ConclusionSpatially-selective universal GRAPE pulses exhibit superior performance compared to kT -spokes pulses. These short and robust pTX pulses hold potential for enhancing a wide range of imaging applications, thereby advancing 7T MRI technology closer to clinical use.