Light-Promoted Dearomative Amination of Nonactivated Arenes via Redox-Neutral Chromium–Nitrenoid Transfer
A light-driven dearomative amination of nonactivated arenes via redox-neutral Cr-nitrenoid transfer is reported. We designed a novel Cr(0) redox-neutral mode that overcomes traditional Cr(0)/Cr(II) redox pathways in dearomatization chemistry using (η 6 -arene)Cr(CO) 3, thereby shifting the electrophile scope from obligatory cationic species to neutral nitrenes for the first time. This strategy enables both dearomative 1,2-hydroamination and 1,2-carboamination with exclusive regio- and stereocontrol, broad functional-group tolerance, and preferential site-selectivity for benzene rings over heteroarenes.
Authors
- Wei‐Long Zeng (ORCID: https://orcid.org/0000-0001-5757-3641)
- Chuqiao Li (ORCID: https://orcid.org/0000-0002-5052-4780)
- Hucheng Wang (ORCID: https://orcid.org/0000-0002-1326-1790)
- Wei Li (ORCID: https://orcid.org/0000-0002-8858-114X)
- Hui Xie
- Ming-Yang Wang
Institutions
- State Key Laboratory of Pollution Control and Resource Reuse (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-17
- DOI
- https://doi.org/10.1021/acs.orglett.6c02572
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China