Which Molecule Is Involved in the Nitrosation Reaction of Pharmaceuticals: NO or NO <sub>2</sub> ?
High Resolution Image Download MS PowerPoint Slide We have previously clearly identified atmospheric nitrogen oxides (NOx) as a key factor in nitrosamine contamination in pharmaceuticals. To implement more appropriate countermeasures, the nitrosation potential of nitrogen monoxide (NO) and nitrogen dioxide (NO 2 )─the primary components of NOx─was evaluated using short-term and long-term gas flow model experiments. The results revealed that NO 2 is required for the nitrosation reaction to occur.
Authors
- Osamu Uchikawa
- Hideyuki Sogo
- R. NOMURA
- Takuma Onai
- Tomohiro Kaku
- Misako Iwazawa
Institutions
- Sumitomo Precision Products (Japan) (JP)
- Towa Pharmaceutical (Japan) (JP)
Publication Details
- Journal
- Organic Process Research & Development
- Published
- 2026-07-17
- DOI
- https://doi.org/10.1021/acs.oprd.6c00108
- Primary Topic
- Water Treatment and Disinfection
- Type
- article
- Field-Weighted Citation Impact
- 0.00