Visible Light-Mediated Enantioselective Alkylation Using a Deaminative Approach: Access to Unnatural Amino Acids and Peptides

) bond formation. While deamination strategies are well explored, asymmetric variants remain underdeveloped. This methodology addresses that gap, delivering high enantioselectivity across a broad substrate scope, including natural product-derived and conformationally constrained scaffolds. The protocol is further applied to the synthesis of unnatural amino acid analogues and polypeptides without a loss of enantiopurity, demonstrating its utility and robustness in asymmetric synthesis.