Construction of Thiophenes and Selenophenes via Iron-Promoted [2+2+1] Cycloaddition of Alkynes with Elemental Chalcogens
and Se to afford multisubstituted heterocycles. A range of 1,6-diynes are tolerated, and a three-component variant using terminal and internal alkynes is also available. This protocol provides a practical approach to thiophenes and selenophenes utilizing earth-abundant iron and elemental chalcogens without additional additives.
Authors
- Kento Ishida (ORCID: https://orcid.org/0000-0002-0000-7304)
- Norio Sakai (ORCID: https://orcid.org/0000-0003-0722-4800)
- Yohei Ogiwara (ORCID: https://orcid.org/0000-0003-1438-0916)
- Kodai Suzuki
- Shurika Innami
- Mayu Otani
- Rikuto Asai
Institutions
- Tokyo University of Science (JP)
- Department of Physics, Mathematics and Informatics (BY)
- Gifu University (JP)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-07-17
- DOI
- https://doi.org/10.1021/acs.orglett.6c02474
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science