Synthesis of 5,6-Disubstituted Bicyclo[2.1.1]Hexanes as Potential Rigidified 1,3-Disubstituted Cyclobutanes
Strategies for the synthesis of 5,6-disubstituted bicyclo[2.1.1]hexanes are presented. These target molecules are of high value because we propose that they might act as rigidified variants of 1,3-disubstituted cyclobutanes. Key to the strategy is the use of a photochemical Wolff rearrangement. Several diastereoselective transformations are provided to showcase their utility.
Authors
- M. Kevin Brown (ORCID: https://orcid.org/0000-0002-4993-0917)
- Shashwati Paul (ORCID: https://orcid.org/0009-0005-0629-7823)
Institutions
- Indiana University Bloomington (US)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-07-17
- DOI
- https://doi.org/10.1021/acs.joc.6c00975
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for the National Institutes of Health
- Indiana University