GPER, 8-isoprostaglandin, and tau protein as potential biomarkers in supraventricular tachycardia: An observational study

Supraventricular tachycardia (SVT) is a common arrhythmic disorder characterized by abnormal electrical impulses arising from supraventricular tissues, most commonly the atria or atrioventricular node. This study aimed to investigate the association between G protein-coupled estrogen receptor (GPER) levels and biomarkers of oxidative stress and neurodegeneration in the pathophysiology of SVT. This study included 51 patients diagnosed with SVT and 30 healthy controls. Plasma levels of the oxidative stress marker 8-iso-prostaglandin F2α (8-iso-PGF2α), the neurodegeneration-associated protein Tau, and GPER were measured using ELISA kits. Correlations between GPER and the studied biomarkers were analyzed, and the diagnostic performance of each biomarker was evaluated using ROC analysis. Pro-BNP levels were higher in patients with SVT compared to the control group (P = .05). GPER, Tau, and 8-iso-PGF2α levels were significantly higher in the SVT group compared to the control group (P < .001 for all 3 biomarkers). ROC analysis demonstrated that 8-iso-PGF2α had the highest diagnostic accuracy, while Tau (AUC = 0.986) and GPER (AUC = 0.981) also showed strong discriminative performance. GPER, a well-established marker of estrogen-mediated cellular signaling, emerges as a significant biomarker in patients with SVT. These findings suggest that GPER-mediated signaling pathways may be associated with systemic oxidative damage and neuronal effects in the pathophysiology of SVT.