Engineered Bacteroides thetaiotaomicron for Targeted Elimination of Fusobacterium nucleatum and Prevention of Colorectal Cancer

The S100 Therapeutic Pill is a novel engineered Bt-based therapeutic for targeting F. nucleatum and preventing colorectal cancer. The design includes 4 genomic edits: pyrE deletion (uracil auxotrophy), tdk replacement with SQR/FRD operon (H₂S detoxification), dnaE TAG at codon #2 (ncAA auxotrophy), and ompA thinning (hypervesiculation). The pill formulation includes sodium fumarate, uracil, and a non-canonical amino acid, with a pH-responsive coating for colonic release. Absolute biocontainment with 10⁻³² escape probability. Inventor: Andrei Valentin Irimia, Rădăuți, Romania. DOI: 10.5281/zenodo.21414869.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-07-17
DOI
https://doi.org/10.5281/zenodo.21414895
Primary Topic
Cancer Research and Treatments
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article
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article

Engineered Bacteroides thetaiotaomicron for Targeted Elimination of Fusobacterium nucleatum and Prevention of Colorectal Cancer

Irimia Andrei Valentin Irimia
Zenodo (CERN European Organization for Nuclear Research)
Cancer Research and Treatments
article

Engineered Bacteroides thetaiotaomicron for Targeted Elimination of Fusobacterium nucleatum and Prevention of Colorectal Cancer

Irimia Andrei Valentin Irimia
article en

Abstract

The S100 Therapeutic Pill is a novel engineered Bt-based therapeutic for targeting F. nucleatum and preventing colorectal cancer. The design includes 4 genomic edits: pyrE deletion (uracil auxotrophy), tdk replacement with SQR/FRD operon (H₂S detoxification), dnaE TAG at codon #2 (ncAA auxotrophy), and ompA thinning (hypervesiculation). The pill formulation includes sodium fumarate, uracil, and a non-canonical amino acid, with a pH-responsive coating for colonic release. Absolute biocontainment with 10⁻³² escape probability. Inventor: Andrei Valentin Irimia, Rădăuți, Romania. DOI: 10.5281/zenodo.21414869.

Zenodo (CERN European Organization for Nuclear Research)
Responsible consumption and production
Openalex Percentile: Top 12%
Cancer Research and Treatments
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Engineered Bacteroides thetaiotaomicron for Targeted Elimination of Fusobacterium nucleatum and Prevention of Colorectal Cancer — Irimia Andrei Valentin Irimia · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS