Altered Plasma Urea Cycle Metabolites Are Independently Associated With Frailty in Patients With Heart Failure
Background: Frailty is common in patients with heart failure and is associated with adverse outcomes. Although metabolic dysregulation has been implicated in frailty, the relationship between plasma amino acid profiles and frailty remains incompletely defined.
Authors
- Hidemichi Kouzu (ORCID: https://orcid.org/0000-0001-7815-1464)
- Nobutaka Nagano
- Suguru Honma (ORCID: https://orcid.org/0000-0001-8455-6943)
- Ryo Numazawa (ORCID: https://orcid.org/0009-0002-7238-1589)
- Satoshi Katano (ORCID: https://orcid.org/0000-0002-2562-1685)
- Ryohei Nagaoka (ORCID: https://orcid.org/0009-0002-0740-8677)
- Kotaro Yamano (ORCID: https://orcid.org/0009-0006-2637-2568)
- Yasunori Umemoto (ORCID: https://orcid.org/0000-0002-8005-9154)
- Takefumi Fujito (ORCID: https://orcid.org/0000-0001-8224-3767)
- Aki Habaguchi
- Katsuhiko Ohori
- T Yano
- Masato Furuhashi
Institutions
- Sapporo Medical University (JP)
- Cardiovascular Center Hokkaido Ohno Hospital (JP)
- Sapporo Medical University Hospital (JP)
Publication Details
- Journal
- Circulation Journal
- Published
- 2026-07-16
- DOI
- https://doi.org/10.1253/circj.cj-26-0329
- Primary Topic
- Dialysis and Renal Disease Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science