Recent advances and clinical applications of 3D printing for female reproductive organ regeneration and gynecological disease

Abstract The integration of three‐dimensional (3D) printing and bioprinting technologies has significantly reshaped the landscape of gynecological medicine, offering innovative strategies to address clinical challenges related to reproductive organ disorders and gynecological malignancies. This review systematically examines recent advancements and clinical applications of 3D printing in female reproductive health, with a focus on tissue engineering and personalized medical solutions for complex gynecological conditions. Specifically, it discusses cutting‐edge developments in 3D bioprinting techniques tailored for regenerating uterine endometrium, ovarian, cervical, vaginal, and pelvic tissues, while highlighting the crucial role of advanced biomaterials, bioinks, and patient‐specific scaffold fabrication. Furthermore, it critically evaluates personalized 3D printing approaches in gynecological oncology, including targeted drug delivery systems, precision brachytherapy applicators, and anatomical models designed to improve surgical outcomes and therapeutic efficacy in endometrial, cervical, and ovarian cancers. Despite significant technological advancements, persistent challenges remain, such as limitations in materials, control over drug release, vascularization strategies, and regulatory hurdles. The review concludes by outlining future research directions, focusing on the integration of advanced imaging, artificial intelligence‐driven design, and multimodal therapeutic platforms. Ultimately, the incorporation of these sophisticated 3D printing solutions into routine clinical practice promises to set new benchmarks in precision gynecology, substantially enhancing patient‐specific therapeutic outcomes and quality of life.