CD36: bridging metabolism, inflammation, and reproduction
Reproductive success requires coordinated regulation of metabolism and inflammation across the ovary, uterus, and placenta. CD36 is a lipid transporter and innate immune receptor that couples fatty acid handling to lipid-inflammation crosstalk. We synthesize mechanistic evidence on how CD36 regulates oocyte competence, endometrial receptivity, and signaling at the maternal-fetal interface, and how its dysregulation contributes to gestational diabetes, preeclampsia, and pregnancy loss, suggesting CD36 as a therapeutic target.
Authors
- Lianghui Diao (ORCID: https://orcid.org/0000-0002-1159-9261)
- Songchen Cai
- Tailang Yin (ORCID: https://orcid.org/0000-0003-2032-0901)
- Yujie Zou (ORCID: https://orcid.org/0000-0002-7024-8023)
- Dongyong Yang
- Qian Liu
Institutions
- Wuhan University (CN)
- Renmin Hospital of Wuhan University (CN)
- Shenzhen Zhongshan Urological Hospital (CN)
Publication Details
- Journal
- npj Metabolic Health and Disease
- Published
- 2026-07-16
- DOI
- https://doi.org/10.1038/s44324-026-00109-1
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province