Successful Endoscopic Submucosal Dissection for Primary Esophageal Mucosa‐Associated Lymphoid Tissue Lymphoma

ABSTRACT Primary esophageal extranodal marginal zone lymphoma of mucosa‐associated lymphoid tissue (MALT lymphoma) is extremely rare, and its optimal management has not been established. We report a case of primary esophageal MALT lymphoma that was successfully treated by endoscopic submucosal dissection (ESD). A 70‐year‐old woman presented with an elevated lesion in the lower esophagus that was detected incidentally on computed tomography. Endoscopy and endoscopic ultrasonography revealed a subepithelial lesion confined to the submucosal layer without apparent invasion of the muscularis propria. Although an endoscopic biopsy suggested a low‐grade lymphoma, a definitive diagnosis could not be established because of the limited tissue volume. Therefore, ESD was performed to obtain an adequate specimen for definitive diagnosis, and complete resection was achieved as a result. Histopathological and immunohistochemical examinations of the resected specimen confirmed primary esophageal MALT lymphoma. The patient has remained in complete remission for 3 years without additional therapy. This case suggests that ESD may be a diagnostic and therapeutic option for primary esophageal MALT lymphoma. Trial Registration : N/A.