CLINICAL AND PATHOGENETIC CHARACTERISTICS OF COMMUNITY-ACQUIRED PNEUMONIA IN CHILDREN WITH UNDERLYING ATOPIC DERMATITIS

This article analyzes the clinical and pathogenetic characteristics of community-acquired pneumonia (CAP) in children with underlying atopic dermatitis based on current scientific evidence. Particular attention is paid to the predominance of the T-helper 2 (Th2)-mediated immune response, impairment of skin and mucosal barrier function, elevated serum immunoglobulin E (IgE) levels, and cytokine imbalance, all of which increase susceptibility to respiratory infections in children with atopic dermatitis. The study also evaluates the clinical manifestations, disease severity, duration, inflammatory biomarkers, laboratory and instrumental diagnostic findings, as well as the risk of complications associated with community-acquired pneumonia in this patient population. The findings indicate that community-acquired pneumonia developing on the background of atopic dermatitis is characterized by a more severe clinical course, prolonged inflammatory response, and the need for comprehensive diagnostic assessment and individualized therapeutic approaches.