Age-Stratified Prognostic Value of Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure

BACKGROUND: ) slope, in patients aged ≥80 years with heart failure (HF) remains unclear. OBJECTIVES: The study evaluated the age-stratified prognostic value of CPET parameters for adverse outcomes in patients with HF. METHODS: In this retrospective multicenter cohort study, we included 830 patients with HF who underwent CPET. The primary outcome was a composite of all-cause death or HF hospitalization within 3 years. CPET parameters were examined in 3 age groups: 20 to 64, 65 to 79, and ≥80 years. RESULTS: slope was comparable across age groups (20-64 years: 0.64 [0.56-0.72], 65-79 years: 0.68 [0.60-0.76], ≥80 years: 0.68 [0.55-0.81]). CONCLUSIONS: was most pronounced in older patients with HF, highlighting the importance of CPET-based risk stratification in this population.

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Publication Details

Journal
JACC Advances
Published
2026-07-16
DOI
https://doi.org/10.1016/j.jacadv.2026.103008
Primary Topic
Cardiovascular and exercise physiology
Type
article
Field-Weighted Citation Impact
0.00

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article

Age-Stratified Prognostic Value of Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure

N Hamazaki, Takenori Ikoma, Yuya Matsue, Momoko Ikeda et al.
JACC Advances
Cardiovascular and exercise physiology
article

Age-Stratified Prognostic Value of Cardiopulmonary Exercise Testing Parameters in Patients With Heart Failure

N Hamazaki, Takenori Ikoma, Yuya Matsue, Momoko Ikeda, Yusuke Mizuno, Kaoru Sato, Kentaro Kamiya, Ichiro Matsumoto, Shoei Yamamoto, Chiharu Noda, K Suzuki, K Kida, T Fujino, Shinjiro Miyazaki, Takashi Miki, Eishin Konishi, Honoka Mibe, Norio Suzuki, Emi Maekawa, Taisuke Nakade, Ken Ogura, Kohei Matsuda
article en

Abstract

BACKGROUND: ) slope, in patients aged ≥80 years with heart failure (HF) remains unclear. OBJECTIVES: The study evaluated the age-stratified prognostic value of CPET parameters for adverse outcomes in patients with HF. METHODS: In this retrospective multicenter cohort study, we included 830 patients with HF who underwent CPET. The primary outcome was a composite of all-cause death or HF hospitalization within 3 years. CPET parameters were examined in 3 age groups: 20 to 64, 65 to 79, and ≥80 years. RESULTS: slope was comparable across age groups (20-64 years: 0.64 [0.56-0.72], 65-79 years: 0.68 [0.60-0.76], ≥80 years: 0.68 [0.55-0.81]). CONCLUSIONS: was most pronounced in older patients with HF, highlighting the importance of CPET-based risk stratification in this population.

JACC AdvancesVol. 5(8)
Twitter (United States) (US), Hamamatsu University (JP), Kyushu University (JP), St. Marianna University School of Medicine (JP), Hamamatsu University School of Medicine (JP), Juntendo University (JP), Kitasato University Hospital (JP), National Hospital Organization Takamatsu Medical Center (JP), Kitasato University (JP)
Japan Society for the Promotion of Science
Good health and well-being
Openalex Percentile: Top 5%
Cardiovascular and exercise physiology
DOIOpen Access PDFOpenAlex
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