Synthesis of β-Carboline Derivatives via Rh(III)-Catalyzed Csp–Csp <b> <sup>3</sup> </b> Bond Cleavage Using Alkynyl Quinol as C2 Surrogates
A straightforward access to diverse, highly functionalized β-carboline derivatives from 2-indolyl nitrone and alkynyl quinol has been established. This protocol features rhodium(III)-catalyzed Csp–Csp 3 bond cleavage and a Kinugasa-type reaction involving N–O bond cleavage as key steps, enabling the assembly of β-carbolines in moderate to good yields with good anticancer activity.
Authors
- Shengnan Xiang
- Shenyou Nie (ORCID: https://orcid.org/0000-0002-7396-8114)
- Zhonghong Chen (ORCID: https://orcid.org/0009-0009-4759-206X)
- Lida Wang (ORCID: https://orcid.org/0000-0001-5353-1620)
- Yi He (ORCID: https://orcid.org/0000-0001-8722-7213)
- Jiefu Luo
- Chenxiao Jiang
Institutions
- Ministry of Internal Affairs of the Republic of Tajikistan (TJ)
- Target (United States) (US)
- Chongqing Medical University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-07-16
- DOI
- https://doi.org/10.1021/acs.joc.6c01276
- Primary Topic
- Synthesis and bioactivity of alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Science and Technology of the People's Republic of China
- Chongqing Municipal Education Commission
- Venture and Innovation Support Program for Chongqing Overseas Returnees