Reduced Effect of <i>APOE4</i> on White Matter Microstructure in an American Indian Community
Apolipoprotein E4 (APOE4) is central to Alzheimer disease (AD) personalized medicine, yet its link to AD is highly ancestry-dependent. Emerging evidence suggests an attenuated risk of APOE4 on brain health in American Indian (AI) participants. This study examines white matter microstructure, an early indicator of brain health deterioration, among tribal Elders carrying the APOE4 allele.
Authors
- René Labounek (ORCID: https://orcid.org/0000-0003-0439-1304)
- M. Matheson (ORCID: https://orcid.org/0009-0002-9095-5048)
- William G. Mantyh (ORCID: https://orcid.org/0000-0003-2096-2461)
- Adam Hansen (ORCID: https://orcid.org/0000-0002-4358-9842)
- Ashley Petersen (ORCID: https://orcid.org/0000-0001-7711-9657)
- Christophe Lenglet (ORCID: https://orcid.org/0000-0003-4646-3185)
- Igor Nestrašil (ORCID: https://orcid.org/0000-0002-3833-1484)
- Adam D. Block (ORCID: https://orcid.org/0009-0006-6447-4952)
- Annamarie Hill
- J. Neil Henderson (ORCID: https://orcid.org/0000-0002-9974-4709)
- Ann J. Robertson
- Corey A. Strong (ORCID: https://orcid.org/0009-0006-7991-0227)
Institutions
- University of Minnesota (US)
- Fond du Lac Reservation (US)
- Global Strategy Group (US)
- Neurobehavioral Systems (US)
- Minnesota Department of Health (US)
- Resonance Research (United States) (US)
Publication Details
- Journal
- Neurology Genetics
- Published
- 2026-07-16
- DOI
- https://doi.org/10.1212/nxg.0000000000200418
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 9.61