Spontaneous Takotsubo Syndrome and Its Recurrences: Pathogenetic Role of Intraventricular Mechanical Factors

might have harbored pre-existing myocardial conditions and associated intraventricular gradient (overt or latent). 1 We wonder whether the authors 1 would evaluate these patients with advanced imaging modalities such as cardiac magnetic resonance imaging and provocation tests.In summary, the evolution of spontaneous TTS episodes, particularly those with a recurrent nature, may suggest a pathogenetic role of intraventricular mechanical factors such as sudden intraventricular obstruction.Timely diagnosis of pre-existing myocardial conditions, along with management strategies against sudden intraventricular obstruction, may prevent future TTS recurrences.