The Association Between <i>APOE</i> Genotype, Race, and Dementia
The apolipoprotein E (APOE) haplotypes are known to be associated with dementia, with the ε4 haplotype associated with higher risk. It has been suggested that the APOE ε2 allele serves as a protective factor for dementia. However, data on the effects of the homozygous APOE ε2/ε2 genotype are limited, likely due to the rarity of the APOE ε2/ε2 genotype. Furthermore, the association between APOE genotypes and dementia may differ across self-reported race. We aim to investigate the association between APOE genotypes and dementia overall and across self-reported race, with a focus on the potential protective effects of the ε2 haplotype and differences across race.
Authors
- Vilmundur Guðnason (ORCID: https://orcid.org/0000-0001-5696-0084)
- Sudha S. Seshadri (ORCID: https://orcid.org/0000-0001-6135-2622)
- Allison E. Aiello (ORCID: https://orcid.org/0000-0001-7029-2537)
- Alden L. Gross (ORCID: https://orcid.org/0000-0002-4678-0562)
- Lenore J. Launer (ORCID: https://orcid.org/0000-0002-3238-7612)
- Alison E. Fohner (ORCID: https://orcid.org/0000-0003-4231-3331)
- Catherine Helmer (ORCID: https://orcid.org/0000-0002-5169-7421)
- Denise M. Scholtens (ORCID: https://orcid.org/0000-0002-8252-7863)
- Farzaneh A. Sorond (ORCID: https://orcid.org/0000-0002-6127-0739)
- Emily M. Briceño (ORCID: https://orcid.org/0000-0002-9360-8917)
- Norrina B. Allen (ORCID: https://orcid.org/0000-0002-6993-4384)
- M. Arfan Ikram (ORCID: https://orcid.org/0000-0003-0372-8585)
- Aïcha Soumaré (ORCID: https://orcid.org/0000-0002-0178-6506)
- John Stephen (ORCID: https://orcid.org/0000-0001-7309-9193)
- Katherine Giorgio (ORCID: https://orcid.org/0000-0002-1815-4732)
- Rachel Zmora (ORCID: https://orcid.org/0000-0002-2553-2471)
- Djass Mbangdadji
- Paul S. de Vries (ORCID: https://orcid.org/0000-0003-0964-0111)
- Archana Singh‐Manoux (ORCID: https://orcid.org/0000-0002-1244-5037)
- Lihui Zhao (ORCID: https://orcid.org/0000-0002-6877-9490)
- Timothy M. Hughes (ORCID: https://orcid.org/0000-0002-2919-7199)
- Maxwell Armand Mansolf (ORCID: https://orcid.org/0000-0001-6861-8657)
- Suzanne E. Judd (ORCID: https://orcid.org/0000-0001-7594-6587)
- Stéphanie Debette (ORCID: https://orcid.org/0000-0001-8675-7968)
- Pamela L. Lutsey (ORCID: https://orcid.org/0000-0002-1572-1340)
- Sanaz Sedaghat (ORCID: https://orcid.org/0000-0002-8296-1811)
- Michael Griswold (ORCID: https://orcid.org/0000-0001-8106-5516)
- Natalia Lakomski
- Oscar L. López (ORCID: https://orcid.org/0000-0002-8546-8256)
- Zhiguang Li (ORCID: https://orcid.org/0000-0003-2474-3485)
- Deborah A. Levine (ORCID: https://orcid.org/0000-0002-6864-8001)
- Elizabeth Peterson (ORCID: https://orcid.org/0000-0001-7831-9079)
- Claudia L. Satizábal (ORCID: https://orcid.org/0000-0002-1115-4430)
- Jayandra J. Himali
- Frank J. Wolters (ORCID: https://orcid.org/0000-0003-2226-4050)
- D Lloyd-jones
Institutions
- Boston University (US)
- Northwestern University (US)
- Reykjavík University (IS)
- National Institutes of Health (US)
- University of Minnesota (US)
- Alabama Department of Public Health (US)
- Johns Hopkins University (US)
- Université de Bordeaux (FR)
- Inserm (FR)
- University of Iceland (IS)
- The University of Texas at San Antonio Health Science Center (US)
- University of Pittsburgh (US)
- University of Washington (US)
- Université Paris Cité (FR)
- University of Michigan (US)
- Erasmus MC (NL)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- University of Alabama at Birmingham (US)
- Sorbonne Paris Cité (FR)
- Bordeaux Population Health (FR)
- Institute for Neurodegenerative Disorders (US)
- National Institute on Aging (US)
- Icelandic Heart Association (IS)
- University College London (GB)
- Wake Forest University (US)
- Columbia University (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Neurology Genetics
- Published
- 2026-07-16
- DOI
- https://doi.org/10.1212/nxg.0000000000200417
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00