Atomistic Simulations Decode the Mechanisms of DNA and RNA Processing Enzymes: Function through Motion

can obviously be extended to other catalytic systems, what is particularly remarkable about these enzymes─even if not unique─is that their functional complexity is handled with extraordinary accuracy through precise motions, despite the system's architectural complexity, on the move. These recent mechanistic findings also provide insights into how to engineer or modulate these enzymes, with implications for several scientific activities centered on nucleic acid chemistry.

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Publication Details

Journal
Accounts of Chemical Research
Published
2026-07-16
DOI
https://doi.org/10.1021/acs.accounts.6c00391
Primary Topic
DNA and Nucleic Acid Chemistry
Type
article
Field-Weighted Citation Impact
0.00

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article

Atomistic Simulations Decode the Mechanisms of DNA and RNA Processing Enzymes: Function through Motion

Marco De Vivo
Accounts of Chemical Research
DNA and Nucleic Acid Chemistry
article

Atomistic Simulations Decode the Mechanisms of DNA and RNA Processing Enzymes: Function through Motion

Marco De Vivo
article en

Abstract

can obviously be extended to other catalytic systems, what is particularly remarkable about these enzymes─even if not unique─is that their functional complexity is handled with extraordinary accuracy through precise motions, despite the system's architectural complexity, on the move. These recent mechanistic findings also provide insights into how to engineer or modulate these enzymes, with implications for several scientific activities centered on nucleic acid chemistry.

Accounts of Chemical Research
Italian Institute of Technology (IT)
Fondazione AIRC per la ricerca sul cancro ETS
Openalex Percentile: Top 14%
DNA and Nucleic Acid Chemistry
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