Atomistic Simulations Decode the Mechanisms of DNA and RNA Processing Enzymes: Function through Motion
can obviously be extended to other catalytic systems, what is particularly remarkable about these enzymes─even if not unique─is that their functional complexity is handled with extraordinary accuracy through precise motions, despite the system's architectural complexity, on the move. These recent mechanistic findings also provide insights into how to engineer or modulate these enzymes, with implications for several scientific activities centered on nucleic acid chemistry.
Authors
- Marco De Vivo (ORCID: https://orcid.org/0000-0003-4022-5661)
Institutions
- Italian Institute of Technology (IT)
Publication Details
- Journal
- Accounts of Chemical Research
- Published
- 2026-07-16
- DOI
- https://doi.org/10.1021/acs.accounts.6c00391
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fondazione AIRC per la ricerca sul cancro ETS