Zuogui Pill Modulates Osteoblast-Osteoclast Coupling in Ovariectomized Rats: A Three by Three Factorial Study
This study evaluates the effects of Zuogui Pill on postmenopausal osteoporosis in ovariectomized rats using a three-by-three factorial design. The results support synergistic effects of Yin- and Yang-components on bone metabolism and associated EphB4/ephrinB2 pathway markers, although mechanistic evidence remains associative rather than causal.
Authors
- Chongyang Dong
- Zengliang Zhang
- Jianjun Chen
- Xiongyao Wang
- Xueli Zhang
- Xiaoming Gao
Publication Details
- Journal
- Journal of Visualized Experiments
- Published
- 2026-09-11
- DOI
- https://doi.org/10.3791/72226
- Primary Topic
- Axon Guidance and Neuronal Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00