A journey through the molecular networks of endomyocardial biopsies to explore ATTR and AL<i>λ</i> cardiac amyloidosis.
and ATTR conditions, respectively. These findings corroborate previously proposed pathological mechanisms, namely, direct mitochondrial toxicity of light chain fibrils internalized via macropinocytosis and massive extracellular deposition of ATTR. Notably, protein quantification and network topology enabled the identification of potential disease markers. Although the selection criteria were robust, validation in larger cohorts is needed. Nevertheless, given the challenging accessibility of the analyzed samples, the proposed landscape of results provides a valuable resource to encourage further studies on cardiac amyloidosis.
Authors
- Francesca Brambilla (ORCID: https://orcid.org/0000-0002-9532-175X)
- Joakim Sandstedt (ORCID: https://orcid.org/0000-0002-6458-9550)
- Göran Larson (ORCID: https://orcid.org/0000-0002-2616-0366)
- Kristina Vukušić (ORCID: https://orcid.org/0000-0002-4243-0565)
- Kristjan Karason (ORCID: https://orcid.org/0000-0002-2802-1191)
- Saleh Hamed (ORCID: https://orcid.org/0000-0003-1128-5489)
- Raffaello Viganò (ORCID: https://orcid.org/0009-0003-2833-5750)
- Emanuele Bobbio (ORCID: https://orcid.org/0000-0002-8287-2448)
- Fredrik Noborn (ORCID: https://orcid.org/0000-0002-8978-8337)
- Anders Oldfors (ORCID: https://orcid.org/0000-0002-5758-7397)
- Pierluigi Mauri (ORCID: https://orcid.org/0000-0003-4364-0393)
- Andrea Lomagno (ORCID: https://orcid.org/0009-0007-5807-7827)
- Dario Di Silvestre
- Jonas Nilsson
Institutions
- Sahlgrenska University Hospital (SE)
- Institute for Experimental Endocrinology and Oncology (IT)
- Institute of Biomedical Technologies (IT)
- University of Gothenburg (SE)
Publication Details
- Journal
- PubMed
- Published
- 2026-07-17
- DOI
- https://doi.org/10.1016/j.isci.2026.116573
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00