Beyond Medication: Integrative and Nutrition Therapies for Disorders of Gut-Brain Interaction.

Disorders of gut-brain interaction (DGBIs), such as irritable bowel syndrome and functional dyspepsia, affect a substantial portion of the global population. These disorders are best conceptualized through a biopsychosocial framework, reflecting the complex interplay and bidirectional communication among biological, psychological, and social factors. While conventional pharmaceutical treatments remain limited in efficacy and patient satisfaction, interest in integrative approaches to care continues to grow. However, despite the increasing use of integrative interventions for DGBIs, their therapeutic targets and underlying mechanisms remain poorly defined. This article aims to describe current and emerging integrative and nutrition-based interventions for DGBIs and evaluate their potential to complement conventional medicine by addressing a broader spectrum of biopsychosocial risk factors.