146P Dynamic folate receptor-α (FRα) expression in recurrent ovarian cancer patients undergoing secondary debulking surgery: A real-world analysis

FRα is a clinically actionable target in ovarian cancer, with mirvetuximab soravtansine approved in patients with high expression based on PS2 scoring. However, FRα expression may be heterogeneous and dynamic. Real-world data on FRα expression patterns and their clinical implications remain limited We evaluated temporal changes in FRα expression between primary and secondary debulking surgery (SDS).

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Publication Details

Journal
ESMO Open
Published
2026-07-01
DOI
https://doi.org/10.1016/j.esmoop.2026.108193
Primary Topic
Folate and B Vitamins Research
Type
article
Field-Weighted Citation Impact
0.00
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article

146P Dynamic folate receptor-α (FRα) expression in recurrent ovarian cancer patients undergoing secondary debulking surgery: A real-world analysis

A-M. Papanota, D. Haidopoulos, M.A.C. Dimopoulos, A. Michas et al.
ESMO Open
Folate and B Vitamins Research
article

146P Dynamic folate receptor-α (FRα) expression in recurrent ovarian cancer patients undergoing secondary debulking surgery: A real-world analysis

A-M. Papanota, D. Haidopoulos, M.A.C. Dimopoulos, A. Michas, N. Thomakos, M. Liontos, T. Papadopoulou, M. Kaparelou, A. Svarna, D. Papatheodorou, N.G. Dedes, A. Andrikopoulou
article en

Abstract

FRα is a clinically actionable target in ovarian cancer, with mirvetuximab soravtansine approved in patients with high expression based on PS2 scoring. However, FRα expression may be heterogeneous and dynamic. Real-world data on FRα expression patterns and their clinical implications remain limited We evaluated temporal changes in FRα expression between primary and secondary debulking surgery (SDS).

ESMO OpenVol. 11
National and Kapodistrian University of Athens (GR)
Good health and well-being
Openalex Percentile: Top 6%
Folate and B Vitamins Research
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