8P Investigating the potential role of TMEM200A in drug-induced epithelial-mesenchymal transition of ovarian cancer

TMEM200A is a transmembrane protein with limited functional characterization in cancer. We previously showed that ovarian cancer (OC) cell lines with acquired resistance to carboplatin (CBP) display increased TMEM200A expression, while TMEM200A silencing restores drug sensitivity and reduces invasive capacity. This study aimed to investigate in more detail TMEM200A-regulated drug response and epithelial–mesenchymal transition.

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Publication Details

Journal
ESMO Open
Published
2026-07-01
DOI
https://doi.org/10.1016/j.esmoop.2026.108033
Primary Topic
Cancer Cells and Metastasis
Type
article
Field-Weighted Citation Impact
0.00
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article

8P Investigating the potential role of TMEM200A in drug-induced epithelial-mesenchymal transition of ovarian cancer

S. Emir, J. Baranasic, A. Brozovic, P. Jadrijevic - Mladar et al.
ESMO Open
Cancer Cells and Metastasis
article

8P Investigating the potential role of TMEM200A in drug-induced epithelial-mesenchymal transition of ovarian cancer

S. Emir, J. Baranasic, A. Brozovic, P. Jadrijevic - Mladar, N. Karakas
article en

Abstract

TMEM200A is a transmembrane protein with limited functional characterization in cancer. We previously showed that ovarian cancer (OC) cell lines with acquired resistance to carboplatin (CBP) display increased TMEM200A expression, while TMEM200A silencing restores drug sensitivity and reduces invasive capacity. This study aimed to investigate in more detail TMEM200A-regulated drug response and epithelial–mesenchymal transition.

ESMO OpenVol. 11
Istanbul Medipol University (TR), Ruđer Bošković Institute (HR)
Good health and well-being
Openalex Percentile: Top 8%
Cancer Cells and Metastasis
DOIOpen Access PDFOpenAlex
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