Research on the Mechanism of Natural Products Acting on Chronic Obstructive Pulmonary Disease

ABSTRACT Chronic obstructive pulmonary disease (COPD) is one of the major health problems worldwide. Its pathological process involves multiple mechanisms such as oxidative stress, chronic airway inflammation, airway remodeling, and excessive mucus secretion. Current clinical therapeutic drugs have limitations in curbing the progression of the disease. An increasing number of studies have shown that natural products, due to their multi‐target synergistic regulatory characteristics and good biological safety, have shown important research value and application potential in the prevention and treatment of COPD. This article discusses the potential therapeutic effects of about 80 natural compounds from plants, microorganisms, animals, and marine organisms on COPD, and summarizes more than 350 references to analyze their potential mechanisms.