17P Single-cell profiling guides a disease-tailored TCR-based immunotherapy for epithelial ovarian cancer

Epithelial ovarian cancer (EOC) is characterized by a profoundly immunosuppressive tumor microenvironment. Although T-cell infiltration is a key prognostic factor, the hierarchical contribution of specific inhibitory receptors (IRs) to T-cell dysfunction—and their relative impact on therapeutic redirection—remains unclear.

Authors

B. Shultes
A. Simioni
Z. Magnani
G. Pavone (ORCID: https://orcid.org/0000-0002-7901-5285)
A. Bergamini
L. Perani
D. Abbati
M Candiani
L. Bocciolone
M. Sant' Angelo
C. Balestrieri
M.C.C. Maffia
E. Tassi
C. Doglioni
B. Camisa
G. Candotti
C. Bonini
A. Prodeus
F. Sanvito
E. Ruggiero

Institutions

Vita-Salute San Raffaele University (IT)
Intellia Therapeutics (United States) (US)
IRCCS Ospedale San Raffaele (IT)

Publication Details

Journal: ESMO Open
Published: 2026-07-01
DOI: https://doi.org/10.1016/j.esmoop.2026.108042
Primary Topic: Single-cell and spatial transcriptomics
Type: article
Field-Weighted Citation Impact: 0.00

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article

17P Single-cell profiling guides a disease-tailored TCR-based immunotherapy for epithelial ovarian cancer

B. Shultes, A. Simioni, Z. Magnani, G. Pavone et al.

Jul 1, 2026

ESMO Open

Single-cell and spatial transcriptomics

article

17P Single-cell profiling guides a disease-tailored TCR-based immunotherapy for epithelial ovarian cancer

B. Shultes, A. Simioni, Z. Magnani, G. Pavone, A. Bergamini, L. Perani, D. Abbati, M Candiani, L. Bocciolone, M. Sant' Angelo, C. Balestrieri, M.C.C. Maffia, E. Tassi, C. Doglioni, B. Camisa, G. Candotti, C. Bonini, A. Prodeus, F. Sanvito, E. Ruggiero

July 1, 2026article en

Abstract

Epithelial ovarian cancer (EOC) is characterized by a profoundly immunosuppressive tumor microenvironment. Although T-cell infiltration is a key prognostic factor, the hierarchical contribution of specific inhibitory receptors (IRs) to T-cell dysfunction—and their relative impact on therapeutic redirection—remains unclear.

ESMO OpenVol. 11

Vita-Salute San Raffaele University (IT), Intellia Therapeutics (United States) (US), IRCCS Ospedale San Raffaele (IT)

Good health and well-being

Openalex Percentile: Top 11%

Single-cell and spatial transcriptomics

DOI Open Access PDF OpenAlex

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