7P Inhibition of glycolysis and stimulation of mitochondrial biogenesis induce ROS-dependent selective cell death in HNF-1β–positive clear cell carcinoma

Ovarian clear cell carcinoma (OCCC) is characterized by HNF-1β overexpression and marked resistance to conventional chemotherapy, underscoring the need for novel therapeutic strategies. Actinonin, an inhibitor of aminopeptidase M and peptide deformylase, has emerged as a potential anticancer agent. This study investigated whether combined inhibition of GSK-3β and Actinonin could selectively target HNF-1β–driven clear cell carcinoma.