The Clinical Impact of Prognostic Nutritional Index at Recurrence of Pancreatic Cancer.

Background/Aim: Most patients with pancreatic cancer experience recurrence after curative surgical resection. Nutritional-related indicators have been evaluated to analyze prognosis in pancreatic cancer. However, it is unknown whether the cachexia index (CXI) or the prognostic nutritional index (PNI) is better for prediction of survival in patients with recurrence of pancreatic cancer. In this study, we compared the ability of the PNI to predict survival at 1 year after recurrence of pancreatic cancer with that of the CXI. Patients and Methods: The study included 113 patients whom we retrospectively identified to have developed recurrence of pancreatic cancer as of September 2025 following pancreatectomy at our Institution between July 2005 and December 2022. Results: =0.006). Conclusion: Patients with a low PNI at the time of recurrence of pancreatic cancer have poorer prognostic outcomes than those with a high PNI. Improvement of nutritional status after curative surgery might improve prognosis after recurrence of pancreatic cancer.