154P Ocular toxicity related to mirvetuximab soravtansine in ovarian cancer: A real-world analysis

Mirvetuximab soravtansine (MIRV) is an antibody-drug conjugate targeting folate receptor alpha (FRα), approved for the treatment of patients with FRα-positive platinum-resistant ovarian cancer. Ocular adverse events are common with MIRV and may require dose modifications. Real-world data on incidence, predictors and clinical impact remain limited. Therefore, the aim of this study was to address these gaps, including their association with treatment response, in patients receiving MIRV in a real-world setting.

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Journal
ESMO Open
Published
2026-07-01
DOI
https://doi.org/10.1016/j.esmoop.2026.108201
Primary Topic
HER2/EGFR in Cancer Research
Type
article
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0.00
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article

154P Ocular toxicity related to mirvetuximab soravtansine in ovarian cancer: A real-world analysis

M. Cocuzza, M T Perri, CM Sassu, S M Boccia et al.
ESMO Open
HER2/EGFR in Cancer Research
article

154P Ocular toxicity related to mirvetuximab soravtansine in ovarian cancer: A real-world analysis

M. Cocuzza, M T Perri, CM Sassu, S M Boccia, V. Salutari, M.V. Carbone, A. Fagotti, F. De Dominicis, A. Giustozzi, V. Iacobelli, T. Salgarello, A. De Palma, C. Marchetti, A. Giudiceandrea
article en

Abstract

Mirvetuximab soravtansine (MIRV) is an antibody-drug conjugate targeting folate receptor alpha (FRα), approved for the treatment of patients with FRα-positive platinum-resistant ovarian cancer. Ocular adverse events are common with MIRV and may require dose modifications. Real-world data on incidence, predictors and clinical impact remain limited. Therefore, the aim of this study was to address these gaps, including their association with treatment response, in patients receiving MIRV in a real-world setting.

ESMO OpenVol. 11
Università Cattolica del Sacro Cuore (IT), Agostino Gemelli University Polyclinic (IT)
Good health and well-being
Openalex Percentile: Top 8%
HER2/EGFR in Cancer Research
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