21P Adipose tissue-derived ceramides promote CD8+ T cell exhaustion and tumor progression in obesity-associated ovarian cancer

Obesity is a well-established risk factor for several cancers, but its specific role in the tumor microenvironment (TME) and progression of ovarian cancer (OC) remains poorly understood. This study investigates the mechanistic links between obesity, visceral adipose tissue, and immune dysfunction in OC, combining public database analysis with preclinical models.

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Journal
ESMO Open
Published
2026-07-01
DOI
https://doi.org/10.1016/j.esmoop.2026.108046
Primary Topic
Sphingolipid Metabolism and Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

21P Adipose tissue-derived ceramides promote CD8+ T cell exhaustion and tumor progression in obesity-associated ovarian cancer

N. Wang
ESMO Open
Sphingolipid Metabolism and Signaling
article

21P Adipose tissue-derived ceramides promote CD8+ T cell exhaustion and tumor progression in obesity-associated ovarian cancer

N. Wang
article en

Abstract

Obesity is a well-established risk factor for several cancers, but its specific role in the tumor microenvironment (TME) and progression of ovarian cancer (OC) remains poorly understood. This study investigates the mechanistic links between obesity, visceral adipose tissue, and immune dysfunction in OC, combining public database analysis with preclinical models.

ESMO OpenVol. 11
Chinese University of Hong Kong (HK), University of Hong Kong (HK)
Good health and well-being
Openalex Percentile: Top 11%
Sphingolipid Metabolism and Signaling
DOIOpen Access PDFOpenAlex
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21P Adipose tissue-derived ceramides promote CD8+ T cell exhaustion and tumor progression in obesity-associated ovarian cancer — N. Wang · ESMO Open (2026) | TGRS Research Map | TGRS