The Impact of Comprehensive Panel NGS Testing and Cascade Family Screening on Early Diagnosis of Prostate Cancer and MINAS (<i>ATM+MITF</i>) Management.
Background/Aim: carriership. Materials and Methods: Index patient and family members who have a history of cancer with a familial cancer pedigree were evaluated using a multigene NGS approach. Targeted sequencing was performed on the MGI DNBSEQ-G400 platform using the Twist Bioscience Hereditary Cancer Panel. Results: variant. Conclusion: comprehensive NGS provides tangible clinical benefits by detecting malignancies early in clinically silent carriers.
Authors
- İrem Bilgetekin (ORCID: https://orcid.org/0000-0003-1154-5850)
- Taha Bahsi (ORCID: https://orcid.org/0000-0001-7210-7374)
- Mehmet Ali Ergün (ORCID: https://orcid.org/0000-0001-9696-0433)
- Yusuf Bahap (ORCID: https://orcid.org/0000-0001-8608-2796)
- Ibrahim Güllü
Institutions
- Üsküdar University (TR)
- Memorial Ankara Hospital (TR)
- Hacettepe University (TR)
- Gazi University (TR)
Publication Details
- Journal
- PubMed
- Published
- 2026-07-02
- DOI
- https://doi.org/10.21873/cdp.10574
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00