14P Unravelling mitochondrial DNA mutations in high-grade serous ovarian cancer

Mitochondrial DNA (mtDNA) is a compact, high copy genome with little genetic redundancy. Heteroplasmy reflects a heterogenous mix of mutant and wildtype alleles per cell. MtDNA mutations are prevalent in high-grade serous ovarian cancer (HGSOC), with heteroplasmy levels predictive of survival. We examined the HGSOC mtDNA mutational landscape for mutational burden and patterns.

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Publication Details

Journal
ESMO Open
Published
2026-07-01
DOI
https://doi.org/10.1016/j.esmoop.2026.108039
Primary Topic
Mitochondrial Function and Pathology
Type
article
Field-Weighted Citation Impact
0.00
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article

14P Unravelling mitochondrial DNA mutations in high-grade serous ovarian cancer

C. Gourley, L. Greaves, S.S.P. Low, C. Semple et al.
ESMO Open
Mitochondrial Function and Pathology
article

14P Unravelling mitochondrial DNA mutations in high-grade serous ovarian cancer

C. Gourley, L. Greaves, S.S.P. Low, C. Semple, R. Silk
article en

Abstract

Mitochondrial DNA (mtDNA) is a compact, high copy genome with little genetic redundancy. Heteroplasmy reflects a heterogenous mix of mutant and wildtype alleles per cell. MtDNA mutations are prevalent in high-grade serous ovarian cancer (HGSOC), with heteroplasmy levels predictive of survival. We examined the HGSOC mtDNA mutational landscape for mutational burden and patterns.

ESMO OpenVol. 11
Edinburgh Cancer Research (GB), Wellcome Centre for Mitochondrial Research (GB)
Openalex Percentile: Top 11%
Mitochondrial Function and Pathology
DOIOpen Access PDFOpenAlex
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