Are high doses of naloxone required for nitazene overdoses?

A review was undertaken to assess whether high doses of naloxone are required to treat nitazene overdoses. MEDLINE and EMBASE databases were searched. A Google Scholar search was also conducted. After title and abstract screening, five eligible papers were included. The study details, such as authorship, study country and year of publication, patient group, study type, outcome measures, key results and weaknesses were extracted. Our results suggest that a range of 0.4-4.40 mg of naloxone is required to treat nitazene overdoses. This does not support using higher doses. Further research is needed to validate these findings and explore the impact of dose frequency.