Direct Synthesis of <i>N</i> -Acylhydrazones from <i>N</i> -Substituted Hydrazines, Aldehydes, and Carboxylic Acids via Preferential Imine Formation and Selective Secondary Amine Monoacylation
A three-component reaction of N -substituted hydrazines, aldehydes, and carboxylic acids has been achieved for the synthesis of N -acylhydrazones via the preferential formation of imines and the selective monoacylation of N -substituted hydrazones. The reaction has a wide substrate scope and functional group tolerance. The synthetic utility has been illustrated by the facile construction of valuable bioactive molecules and late-stage functionalization of pharmaceuticals.
Authors
- Yan-Biao Chen
- Fang Wang (ORCID: https://orcid.org/0000-0002-5971-2622)
- Yin-Jia Chen
- Bao‐Dong Cui (ORCID: https://orcid.org/0000-0001-5693-5188)
- Kun Zhang (ORCID: https://orcid.org/0000-0002-6971-1164)
- Yun Zhang (ORCID: https://orcid.org/0009-0005-5669-5125)
- Yong‐Zheng Chen (ORCID: https://orcid.org/0000-0003-1211-3486)
- Chun Hong
- Xue-Qing Mou (ORCID: https://orcid.org/0000-0002-7931-8374)
- Hao-Nan Peng
- Xian-Zao Luo
Institutions
- Zunyi Medical University (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-07-02
- DOI
- https://doi.org/10.1021/acs.joc.6c01080
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guizhou Science and Technology Department