Research progress on the chemical and pharmacological effects of <i>Semen Strychni</i> (Review)

Semen Strychni (family Loganiaceae) has a long-standing history of cultivation in South Asia.The medicinal value of Semen Strychni has attracted extensive attention due to its potential efficacy in the intervention of nervous system diseases, anti-arrhythmia, analgesia, anti-inflammation and antitumor fields.However, research on its pharmacological effects are predominantly limited to in vitro experiments, and a systematic pharmacological exploration of different extracts and monomer compounds from Semen Strychni is lacking.Additionally, notable safety risks exist both before and after the processing of Semen Strychni, thus its clinical application and toxicity mechanisms require further in-depth analysis.The present review comprehensively evaluated the latest research progress on the traditional medicinal history, chemical composition analysis and pharmacological activity of Semen Strychni, and aimed to provide a systematic theoretical reference for the follow-up basic research of Semen Strychni and its industrial application in the pharmaceutical field.