179eP PARP inhibitor–associated therapy-related myeloid neoplasms in ovarian cancer: A multi-centre case series from Eastern India

Though Poly (ADP-ribose) polymerase inhibitors (PARPi) are used in ovarian cancer with DNA damage repair pathway and improve survival outcomes, therapy-related myeloid neoplasms (t-MDS/AML) are emerging as a rare but serious complication. Clinico-demographic profile and therapy have been challenging due to paucity of literature, especially from low middle income countries (LMIC).

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Journal
ESMO Open
Published
2026-07-01
DOI
https://doi.org/10.1016/j.esmoop.2026.108225
Primary Topic
PARP inhibition in cancer therapy
Type
article
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0.00
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article

179eP PARP inhibitor–associated therapy-related myeloid neoplasms in ovarian cancer: A multi-centre case series from Eastern India

N. Singh, L. Moharana, I. Rastogi, S.K. Swain et al.
ESMO Open
PARP inhibition in cancer therapy
article

179eP PARP inhibitor–associated therapy-related myeloid neoplasms in ovarian cancer: A multi-centre case series from Eastern India

N. Singh, L. Moharana, I. Rastogi, S.K. Swain, L. Samantaray, S K Mishra, G. Biswas, S.S. Panda, S.S. Mohanty, S. Harankhedkar, V. Agarwala, S. Dash, M. Chandrakanth, K. Ygl
article en

Abstract

Though Poly (ADP-ribose) polymerase inhibitors (PARPi) are used in ovarian cancer with DNA damage repair pathway and improve survival outcomes, therapy-related myeloid neoplasms (t-MDS/AML) are emerging as a rare but serious complication. Clinico-demographic profile and therapy have been challenging due to paucity of literature, especially from low middle income countries (LMIC).

ESMO OpenVol. 11
Tamil Nadu Dr. M.G.R. Medical University (IN), Mahesh Bhattacharyya Homeopathic Medical College and Hospital (IN), Sparsh Hospital (IN), All India Institute of Medical Sciences Bhubaneswar (IN), Institute of Medical Sciences and Sum Hospital (IN)
No poverty
Openalex Percentile: Top 8%
PARP inhibition in cancer therapy
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