RiskSetDP: session-level differential privacy for survival analysis with risk-set–aware sensitivity control

Real-world survival analysis rarely ends with a single deliverable: practitioners typically publish cohort-level statistics, a deployable time-to-event model, interpretable Kaplan-Meier curves, and, where appropriate, a synthetic table for secondary use. When these heterogeneous outputs are protected through separate per-call differential privacy mechanisms, privacy accounting becomes fragmented and difficult to audit. We present RiskSetDP, a session-level framework that governs accounting, acceptance, and release for survival analysis under one auditable budget in the Rényi-DP domain. All calls are composed once, converted to [Formula: see text] for a single global acceptance check, and, when needed, proportionally scaled with noise recalibration so the complete bundle remains within budget. The framework couples a risk-set-aware differentially private Kaplan-Meier estimator that enforces a minimum risk-set threshold and emphasizes early horizons with isotonic post-processing, a reproducible DP-SGD protocol for horizon-wise risk modeling with standardized clipping, batching, and budget-matched noise, and workload-aware synthetic data generation from selected low-order marginals with a consistency repair step. Experiments on METABRIC and SUPPORT2 show consistent, monotonic gains as the session budget increases: curve errors decrease while concordance improves, model discrimination and especially calibration strengthen, and synthetic fidelity and task utility rise. Ablation studies support the value of risk-set control, post-processing, and session-level coupling, and empirical attack audits provide complementary diagnostics under specific attack models while the formal guarantee remains the session-level DP accounting record. These results indicate that RiskSetDP provides a practical and auditable session-level release workflow for survival analysis on two public cohorts, preserving utility while maintaining an externally verifiable accounting record.

Authors

Institutions

Publication Details

Journal
Scientific Reports
Published
2026-07-01
DOI
https://doi.org/10.1038/s41598-026-60269-4
Primary Topic
Privacy-Preserving Technologies in Data
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

RiskSetDP: session-level differential privacy for survival analysis with risk-set–aware sensitivity control

Zhiheng Luo, Zhixuan Xiao, Wenzhou Duan, Yanglin Sun et al.
Scientific Reports
Privacy-Preserving Technologies in Data
article

RiskSetDP: session-level differential privacy for survival analysis with risk-set–aware sensitivity control

Zhiheng Luo, Zhixuan Xiao, Wenzhou Duan, Yanglin Sun, Zhiwen Ou
article en

Abstract

Real-world survival analysis rarely ends with a single deliverable: practitioners typically publish cohort-level statistics, a deployable time-to-event model, interpretable Kaplan-Meier curves, and, where appropriate, a synthetic table for secondary use. When these heterogeneous outputs are protected through separate per-call differential privacy mechanisms, privacy accounting becomes fragmented and difficult to audit. We present RiskSetDP, a session-level framework that governs accounting, acceptance, and release for survival analysis under one auditable budget in the Rényi-DP domain. All calls are composed once, converted to [Formula: see text] for a single global acceptance check, and, when needed, proportionally scaled with noise recalibration so the complete bundle remains within budget. The framework couples a risk-set-aware differentially private Kaplan-Meier estimator that enforces a minimum risk-set threshold and emphasizes early horizons with isotonic post-processing, a reproducible DP-SGD protocol for horizon-wise risk modeling with standardized clipping, batching, and budget-matched noise, and workload-aware synthetic data generation from selected low-order marginals with a consistency repair step. Experiments on METABRIC and SUPPORT2 show consistent, monotonic gains as the session budget increases: curve errors decrease while concordance improves, model discrimination and especially calibration strengthen, and synthetic fidelity and task utility rise. Ablation studies support the value of risk-set control, post-processing, and session-level coupling, and empirical attack audits provide complementary diagnostics under specific attack models while the formal guarantee remains the session-level DP accounting record. These results indicate that RiskSetDP provides a practical and auditable session-level release workflow for survival analysis on two public cohorts, preserving utility while maintaining an externally verifiable accounting record.

Scientific Reports
Jinan University (CN), Second Affiliated Hospital of Guangzhou Medical University (CN), Guangdong Provincial People's Hospital (CN), Guangzhou Medical University (CN)
Openalex Percentile: Top 5%
Privacy-Preserving Technologies in Data
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.