Switchable <i>N</i> -Haloethylation and C–H Halogenation of NH-Enaminones with 1,2-Dihaloethanes
The switchable reactions between NH-enaminones and 1,2-dihaloethanes (X = Cl and Br) in the form of N -haloethylation and C–H halogenation have been achieved under different conditions. The reactions in the presence of tetraethylammonium bromide (TEAB) and Cs 2 CO 3 lead to N -haloethylation. Meanwhile, the promotion with tetrabutyl ammonium iodide (TBAI) and Et 3 N under air enables the umpolung C–H halogenation in the α-site.
Authors
- Changfeng Wan (ORCID: https://orcid.org/0000-0001-9437-4318)
- Weijun Yao (ORCID: https://orcid.org/0000-0001-6463-2937)
- Jie‐Ping Wan (ORCID: https://orcid.org/0000-0002-9367-8384)
- Yunyun Liu (ORCID: https://orcid.org/0000-0002-5553-1672)
- Wanting Liang
Institutions
- Zhejiang Sci-Tech University (CN)
- Nanjing Forestry University (CN)
- Jiangxi Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-07-01
- DOI
- https://doi.org/10.1021/acs.joc.6c01048
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China