Enzyme-Responsive Chemiluminescent Probes Assembled with Iridium(III) Photosensitizers via Host–Guest Chemistry for Chemiluminescence-Induced Photodynamic Therapy
) selectively generated ROS and elicited potent cytotoxicity in cancerous HeLa cells and spheroids under light-free conditions, with apoptosis as the predominant cell death pathway, while remaining noncytotoxic in normal HEK293 cells. This modular platform couples supramolecular host-guest assembly, enzyme-specific activation, and CRET-induced ROS generation to overcome the limitations of conventional PDT, enabling cancer-selective, light-free therapy.
Authors
- Lawrence Cho‐Cheung Lee (ORCID: https://orcid.org/0000-0002-5046-0676)
- Justin Shum (ORCID: https://orcid.org/0000-0001-5080-0792)
- Eunice Chiu‐Lam Mak (ORCID: https://orcid.org/0000-0002-5011-6971)
- Alex Man‐Hei Yip (ORCID: https://orcid.org/0000-0002-2436-3047)
- Kenneth Kam‐Wing Lo (ORCID: https://orcid.org/0000-0002-2470-5916)
- Yi-Xiang Wang (ORCID: https://orcid.org/0000-0002-4021-4228)
- Qi-Hang Cheng
Institutions
- City University of Hong Kong (HK)
- State Key Laboratory of Synthetic Chemistry (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-06-30
- DOI
- https://doi.org/10.1021/jacs.6c01728
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00